I have originally Dx'd with Fibromyalgia and my neuro is revisiting MS. My PCP started me on Cymbalta to help with the Fibro pain (it did not help with the pain in my muscles but it did help with my mood, depression and seemed to help prevent my migraines). My neuro increased it from 60mg to 90mg to help with the migraine prevention, instead of increasing the Topamax from 300mg to 400mg. I am seldom severely depressed, but my migraines are coming back. lol I do hear that Cymbalta is horrible to wean off of, so it is something to seriously consider and talk to your doctor if he/she decides that you should consider it. Cymbalta is an all or nothing drug, either you do well or you do horrible with it.