There are two parts to an anti-nuclear antibody (ANA) test.

The first is the titre - the larger this number, the more anti-nuclear antibodies are present in the blood. Yours (1:640) is high. The second is the staining pattern of your anti-nuclear antibodies in the nuclei of your cells - that is what "speckled" means.

An abnormal ANA test suggests but is not necessarily diagnostic of an autoimmune disease - systemic lupus erythematosus is a possibility though there are others. Your rheumatologist will probably want to discuss other investigations when you see him/her.

This general information about ANA tests might help you in preparation for your meeting with the rheumatologist; http://www.medicinenet.com/antinucle...dy/article.htm.