[QUOTE=kiwi33;1197915]Hi Mamadebski

My understanding is that Mexiletine is no longer available. It was initially indicated for management of irregular heartbeat and was sometimes used for management of neuropathy.

It seems that it had many possible adverse side-effects -
Which sodium channel mutant do you have - the most common of those linked to peripheral neuropathy are those in Nav1.8 (SCN10A) and Nav1.9 (SCN11A)?



Hello & thank you for your reply. Mexiletine is indeed still being prescribed here in the US because I have been seeing it listed in all of the formularies for prescription insurance companies. I am also currently taking it. It has been 6 days & there are definitely side effects. I have yet to get to a therapeutic dose & still do not have any positive results from taking it, so the jury is out for me.

The sodium channel variant that I have been found to have is the Nav1.7 SCN9a. It is linked to Erythromelalgia & SFN. Has anyone out there been diagnosed with this?