I've been on it for a couple years but don't know if it helps because my symptoms are so variable anyway. Sensory & autonomic neuropathy, positive ANA, positive anti-Ro, and very high anti-DsDNA antibodies. With only neuropathy symptoms, no skin or joint problems, I have no Dx but rheumie says she can't say whether I do or don't have lupus. If my symptoms ever level out I'm going to try going off the plaquenil to see if it makes a difference. Which I doubt because I never noticed any identifiable improvement after starting it. I've never had any side effects from it. Sorry I can't be more helpful!