--that if one is getting improvement (slow nerve regeneration), one might have trouble distinguishing initially, as often the process of small fiber nerve growth cones fighting past and through other tissue can produce parastheses and other weird sensations that might well make one think that one is actually having a flare or getting worse.

In long term retrospect, though, if one is getting regeneration these sensations usually calm as the brain gets used to interpreting signals coming from the new connections. But that may take months or longer.

I would think, given the really slow rate of nerve regeneration even under the best of conditions, one shouldn't rely on seeing different skin biopsy results month to month. Annual repetition seems a good interval (unless one is convinced one is having an acute process that is getting rapidly WORSE).