There is new research being done that shows that sodium channel blockers can alter pain translation when genetic variants are at work for those of us with inherited Neuropathies. Mexilitene is still being used, though not as often, due to the side effects for off-label use to treat neuropathic pain. It was a 50/50 shot that this would work. It has worked for some people. Researchers are currently working on developing more specific sodium channel blockers with less side effects. I am hoping to try something new someday.