Since the onset of CRPS I have had bladder trouble, stomach trouble, dysphasia, migraines that sent me to the ER, skin that has become texturized-extremely dry, wrinkled fingertips and extreme fatigue. I don't believe it is coincidental that a few weeks/months after my accident these problems started.

Recently there has been significant research on the vagas nerve, which connects the bowel and the brain as being involved in autonomic function disorder. I found it interesting that the glia cells were mentioned in connection with the vagas nerve info, the cells that are activated with LDN.

There is speculation that the herpes virus may play a part in attacking the VN causing autonomic nerve dysfunction. I have had herpes simplex 1 since I was in grammar school, so this seems a rational hypothesis to me.