Thanks for your answer.

I think 600mg of the stabilized R-ALA is too much.

100mg-200mg a day is enough for most people. That 600mg suggestion is historical and pertains to those using the old mixture type of ALA called racemic.

You can get a DNA test from 23andme, from MTHFR.net and some other OTC internet companies. It will show if you have the errors, that cause poor methylation in the body. (this you have to determine yourself from the SNPs they give you, as the FDA forbids these companies from "interpreting" medical stuff to the clients.

If you don't have low levels of nutrients like B12, folate, B1, B6 or copper, supplementing is not likely to help much.

Lipoic acid is mostly for those with insulin resistance, or pre and regular diabetes. Benfotiamine is for people who cannot handle carbs or get sick or drink too much alcohol. Thiamine can become low in some people and in the past was actually a treatment for PN.

Those with autoimmune factors, have PN damage due to antibody attacks on the nerves. So antioxidants are thought to be helpful for those people. This is where diet helps...and is similar thinking to those with MS who follow Terry Wahls' plan of eating mostly veggies and fruit.

PN symptoms can arise from food intolerances... gluten, nightshade veggies, or fermented foods which high histamine content. I have a histamine thread in the subforum above.

It gets really complicated therefore to get straight answers anywhere in the medical arena. And there are few doctors who will admit that they gave PN causing drugs to their patients causing a toxic PN.