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Old 06-12-2016, 10:28 AM
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mrsD mrsD is offline
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mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
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My point is that one cannot make sweeping statements about this topic. People vary genetically and some have even been born with infantile spasms and require high B6 therapy for life.

Also those with pyroluria or who take medications known to deplete B6 would have different requirements for it, than those without.
The general families of drugs that are known to deplete B6 are:
estrogens (HRT and birth control pills)
most antibiotics
loop diuretics
Estrogens and the diuretics are most often given long term, but some antibiotic treatments can be long term also (lyme or PANDAs).

This article shows some evaluations for 3 nutrients that often can become toxic depending on dosing.
pyridoxine
niacin
selenium

Toxicology of Micronutrients: Adverse Effects and Uncertainty

One should always question high reported lab results, and have a retest and control handling of the specimen. Labs make errors all the time.

I think the deficiency of B6 is much more common that toxicity issues. Using a keyword of "toxicity of pyridoxine" in PubMed was not very fruitful today.
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