Quote:
Originally Posted by johnt
The results from this trial appear to be very good. But:
- the sample size is very small (12 in the NAC group, 11 in the control group, see Table 1);
- the trial is not blinded, and the size of the reported improvement is similar to the placebo effect reported in other studies;
- the confounding issues of gender, age and C/L use possibly favour the NAC result.
Still, the results are encouraging enough to justify a more powerful trial quickly. In the meantime, it may be worth taking NAC as a "therebo" (possible THERapy or placEBO).
John
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Hi, I have been taken NAC (Free Form) for more than a year and I should say it made me feel some improvement at least in tremor and overall stable. At very beginning I started with 600 mg per day, then, as I read the articles and reports which suggest that for PWP should take 2,400 mg per day in order to see therapeutic effect. I gradually built the dosage. When I hit 1,200 mg per day, my tremor was reduced noticeably. But, when I hit 2,400 mg per day, severe and very painful constipation came. Because of the bad constipation, I quitted NAC for two weeks and now go back to the starting point of 600 mg. Anyone has the similar experience that can better deal with the constipation caused by NAC in large dosage? Or, the dosage itself is questionable at 2,400 mg? Another side effect is running nose, but that is quite easier to deal with...