BTW, things I should have added to my above post: I tested as an excellent candidate for DBS, tremor dominant, meds ineffective, excellent cognition, right age (not too old), etc. In my case, Sinemet had never worked well to control my tremor, and it gave me terrible dystonia (a type of dyskinesia) right away, within a year or so. In fact, though many people believe that C/L works for everyone, my MDS doctor told me that for 60%-80% of those who are tremor dominant, like me, C/L doesn't work. Also, re: the weight gain or loss question, it is known that DBS can cause weight gain, and in my case it definitely has increased appetite and, alas, weight! Another DBS tradeoff...