After five years of struggling to get a diagnosis that fits my symptoms better than RA - I learnt from a very knowledgeable oral medicine doctor this morning that I have gone from being autoantibody negative and occasionally equivocal, to having a clear positive ANA of 1/320. Also my IgG and IgA are both elevated and I am to have a lip biopsy and ultrasound of carotid and salivary glands ASAP to rule out or in Sjogrens Syndrome. Although I don't have the dry mouth and only mildly dry eyes she seemed to know that it is still possible to have Sjogrens. She feels my numb, tingling mouth is part of a progressive small fibre neuropathy and says the neurologist was wrong to dismiss it as mild and say it was caused by previously active RA. She says the positive results suggest Lupus, Vasculitis, Sjogrens or Mixed Connective Tissue disease are all more likely with these blood results. My CRP has crept up to 19 and my PV is 1.98 which is also high I believe. I'm under a new rheumatologist - my fourth in five years.

So can anyone tell me what the significance of an ANA 1/320 might be? I don't have the breakdown of these results yet - just what this oral medicine specialist explained verbally.

I'm struggling with fatigue, chronic constipation, disequilibrium, sweats/ fevers and palpitations with bone and nerve pain in my legs. Otherwise much of me has turned mildly numb, including my mouth and nose. My RA is innactive in my joints now and my rheumatoid factor has gone from a weak positive to negative in five years. I'm not on any disease modifying medication because I've had severe allergic responses to four of these.
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