I know it has been a bit of time since last post on this thread but I wanted to let you know my daughter has been dx with MCAS. We have been searching for answers for her for the last 6-7 years and have seen all kinds of specialists which came up with nothing. One ER doctor did say she had POTS but that was it. We sought out a geneticists Dr. Maulik Shah who ordered a battery of blood and urine test. He recently dx MCAS and has begun treatment. The latest was a very low dosage of Doxepin. Although this is an anti depressant, it has a anti histamine effect at a lower dose. She only takes 20 mg a day. We have seen great reduction in pain and daily symptoms with this. She most recently started on the quercetin bromelain. To early to tell how it will work.

One thing I will say is that after years of searching MCAS was somethng that was never mentioned before we met Dr. Shah. Once he saw this through her testing, (high tryptase levels and histamine levels) it all made perfect sense. All her symptoms finally fit. I would encourage you to push forward with it. Not alot of doctors are familiar with it but there are some out there.