there is some speculation backed up by at least 1 study that heliobacter bacteria can reduce the affect of l-dopa, taking antibiotics helped, but i think another study showed no connection. the point i was making was get back to square 1, if the first dose of regular 25/100 in the morning works, and i assume you have figured out what size that dose is, then it's likely not your digestive system and it's just the complications of advanced pd and/or another medical condition, maybe pre-diabetes? just my opinion. i'm rarely constipated but when i am C/L sometimes doesn't kick in.

i may be wrong but i think tea lessens the affect of C/L for me in my advanced stage, tea has amino acids. if i'm at the point that i have no reserve L-DOPA in my brain and i depend 100% on l-dopa and my brain is destroying L-DOPA as fast as it gets into my brain, then even a tiny amount of interference in absorption can have a major affect.