My immunology NEVER shifted to positive.

And then at the age of 68 I was found to have a DEFICIENT IMMUNE SYSTEM.

I don't have enough immune antibodies in my blood to protect me from infection. I need infusions of blood from donors, every month, to keep from having constant infections..

And my Duke Research Immunologist told me that probably my Deficient Immune System is ATTACKING MY ORGANS/SYSTEMS and damaging them.

My Immune System is probably using cytokines for this attack, but we don't have the tests to identify this, yet. "We use the tests we have, not the tests we need."

And OF COURSE I was dismissed by every Rheumatologist and Neurologist as having 'whatever' "idiopathic stuff". Go home and sleep it off.

I had so many idiopathic things that I felt like a "pathetic idiot".

By the way, the attack of our Immune System, by whatever means, causes INFLAMMATION.

And INFLAMMATION brings three horrors:

PAIN
FATIGUE
DEPRESSION.

Like clockwork they appear with inflammation.

I'm sorry you don't tolerate medications easily. I hope the newer medications to suppress your immune system are more tolerable.

I recommend "How to Be Sick" By Toni Bernhard.

Hugs, ElaineD