Another clinical trial. Not great news for someone 13 years into PD and needs a caretaker. If I had PD, I would be taking 2 grams of curcumin daily until or if they ever come up with something a lot better than Sinemet.

Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model. - PubMed - NCBI

Here we show that curcumin can alleviate alphaS-induced toxicity, reduce ROS levels and protect cells against apoptosis. We also show that both intracellular overexpression of alphaS and extracellular addition of oligomeric alphaS increase ROS which induces apoptosis, suggesting that aggregated alphaS may induce similar toxic effects whether it is generated intra- or extracellulary.

http://www.hindawi.com/journals/ijcb/2012/683097/

Curcumin-glucoside, A Novel Synthetic Derivative of Curcumin, Inhibits α-Synuclein Oligomer Formation: Relevance to Parkinson's Disease (PDF Download Available)

fyi
Parkinson's Disease (PD), Parkinson's Disease Dementia (PDD) & Prodromal PD