Thanks Healthgirl. I was on Plaquenil with methotrexate and latterly on its own for 18 months. It worked well for me but unfortunately it gave me a slow form of anaphylaxis so was forced off it eventually. I've tried four DMARDs altogether now - three would have been drugs used for primary Sjogrens. This is why I'm not that hopeful that a diagnosis of Primary Sjogrens would help my treatment options.