Dr Dobbs- first author on study- emailed to that specific ?-- she said-- laxatives fro constipation only- -implying she saw no reason to use the newer agents with potential side effects without proven benefit. This is with the caveat that t his was a retrospective trial- these agents were used in the final years oof the trial-- so it doesn't mean there is no "special" effect- but there is no data to support--