I gained 28 pounds with Neurontin, I'm usually small, so I found this very upsetting. My pain management doc. then wanted me to try Lyrica, but I felt it was too similar to Neurontin, both chemically and the SE. I tried Cymbalta, but it made me feel dreadfully sick, and upset my ;liver, I finished up with Topamax, 200mg twice a day. Its fine. I still have quite a lot of pain, but its the best option, least side effects. I combine with paracetamol, tramadol, and a small amount of anti depressant. Generally though I really loathe having to take drugs at all. I have fused vertebrae, debenerative spine, and probs with abdominal organs as a result of spiney issues, and a weak left arm. Despite all life is wonderful!!