I normally hang out on the MS forum as I was diagnosed with MS.

For the past few years I've been going through a lot of testing for some sort of autoimmune disease. I had a rheumy diagnose me with Lupus and Sjogren's just by feeling my joints. Needless to say, I got a second opinion. Fast forward to now, things are changing. I had some tests come up positive as well as some on clinical exam. My new rheumy started me on Plaquenil 200 mg in the a.m. and 200 in the p.m. I did a test week as I know an upset stomach is a side effect of Plaquenil. I did 200 mg for a week and did ok. I didn't have any significant bowel issues. I then went to the 400 mg a day and did ok, or so I thought. I have now been on Plaquenil for 4 weeks and my digestive system is not happy. I took a few days off to see if things calmed down and if, in fact, it was the medication causing the trouble or if I had something else going on that needed to be addressed. By the 4th day, things settled down. I started back up and so did the digestive issues. It could just be coincidental but I also don't want to go off the medication if it is protecting me from a flare up of whatever connective tissue disease I have.

My questions - For those who took or take Plaquenil, how long did the side effects last? Did they every calm down? What doses are you on as I'm wondering in my 400 mg a day is too much for me. Do you have any other advice or tips, other than to see my ophthalmologist every year, while taking this medicine?