It's been two years since I last posted in this thread. Let's see what's happened since.
Under similar conditions to those reported in previous posts - while "off" take 75mg Stalevo dissolved in vitamin C (details in the Appendix) - the speed that I can side to side tap was measured every 10 minutes over the course of a single drug dose.
StalevoVitC.png
The results show that my tapping speed has increased over time. The main factor behind this appears to be due to a faster tapping rate while "off", rather than an improved effectiveness of the drug.
While there are great statistical weaknesses with this one off test, the results are in line with my scores in other tap tests that I do. As has been mentioned before, I think the most likely reason for the higher score is that I am training myself to do better at this test. However, this raises an interesting question: when do positive test scores promote the testing program into being a therapy itself?
Appendix
Here lives dragons!
Results
Data collected on 19th August, 2016, starting at (T-20) 0630. Previous doses: of Stalevo 13 hours before this one; ropinirole CR and rasagiline 23 hours.
Baseline (3 readings). The set of results 2013 (Post #11) are in [].
Mean left = 22.26 [14.34] taps, right = 17.23 [12.95] taps
After taking the pill until return to baseline (15 readings)
Mean left = 31.78 [25.28], right = 22.88 [19.15]
Max left = 37.69 [32.08], right = 28.56 [25.81]
First minor effect not seen, I went abruptly from "off" to "on" [seen 15 minutes after drinking the liquid].
First major effect seen after 50 [40] minutes.
Peak reached after 50 [70] minutes.
Back to baseline results after 150 [150] minutes.
Correlation left/right = 0.977 [0.960]
The area under the curve and above the baseline (gives a measure of the drug's total effect) = 2125 [2570] taps. This figure can be interpreted as the number of extra taps that 75mg of Stalevo buys me.
Endogenous ratio 72% [61%]
Time,LH_Taps,RH_Taps
-20,22.02,17.92
-10,21.59,16.87
0,23.17,16.89
10,24.86,16.07
20,24.42,17.09
30,25.13,17.52
40,24.93,16.27
50,37.67,28.56
60,37.69,26.62
70,36.07,26.48
80,34.85,25.06
90,34.54,25.42
100,36.43,25.54
110,35.76,25.80
120,31.08,23.24
130,32.59,25.58
140,29.01,21.04
150,21.62,14.71
160,18.68,14.41
170,20.03,15.69
180,20.74,15.21
200,21.29,15.83
John