I started on Permax, an older agonist. I was nauseous for most of the year my MDS kept me on it and lost a lot of weight. He was convinced that there was no difference between Permax, Mirapex and Requip. I finally got my family doctor to switch me to Mirapex and the nausea was rapidly gone. I managed my PD for years with tiny increases in Mirapex. Now I've been decreasing it a tiny bit (1.5 mg three times a day to as little as 0.75 mg in the evening as my dyskinesia gets worse. I'm not sure if it 's worse because that's what happens with the passage of time or because my high cadence cycling is making me better and I don't need so much medication. I'll find out if other symptoms improve even more.

By the way, Permax isn't around anymore, they discovered it could damage heart valves.