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Member
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Join Date: Aug 2006
Posts: 241
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Member
Join Date: Aug 2006
Posts: 241
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Hi Kim..here's some more recent studies....
Coeliac children on a gluten-free diet with or without oats display equal anti-avenin antibody titres. (2006)
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum
Quote:
1: Scand J Gastroenterol. 2006 Jan;41(1):42-7. Links
Hollen E,
Holmgren Peterson K,
Sundqvist T,
Grodzinsky E,
Hogberg L,
Laurin P,
Stenhammar L,
Falth-Magnusson K,
Magnusson KE.
Division of Medical Microbiology, Linkoping University, Sweden. eliho@imk.liu.se
OBJECTIVE: Recent studies report negligible toxicity of oats in the majority of coeliac disease (CD) patients. It has previously been shown that children with untreated CD have circulating antibodies to oats avenin. In this study we performed serial assessments of anti-avenin antibodies in children under investigation for CD on a gluten-free diet with or without oats.
MATERIAL AND METHODS: The study involved 116 children, randomized to a standard gluten-free diet or a gluten-free diet supplemented with oats. Sera were obtained from 86 children, 48 in the standard gluten-free group and 38 in the gluten-free oats group, of which 33 consumed at least 10 g of oats daily. IgA and IgG anti-avenin antibodies were monitored at 0, 3, 6 and 12 months. Nitric oxide metabolites were measured in 7 patients, with deviating antibody results.
RESULTS: There was a significant decrease in anti-avenin antibodies in both groups at the end as compared to the beginning of the study, (p<0.001), but no difference was found between the two groups. IgA titres already declined after 3 months. IgG titres, although significantly decreased, remained high in the majority of patients in both groups. Nitric oxide levels were high in four of the analysed samples.
CONCLUSIONS: Oats per se, do not seem to produce a humoral immune reaction in children with CD when given in an otherwise gluten-free diet, indicating that the reaction requires gluten challenge. Anti-avenin antibodies were equal in the two study groups, and these findings strengthen the clinical impression that oats can be tolerated by the majority of patients with CD.
PMID: 16373275 [PubMed - indexed for MEDLINE]
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Hmmm, they checked the IgA and IgG anti-avenin antibodies, but what about the IgA and IgG anti-gliadin antibodies?? Might have been interesting to check those. Or did they use pure GF oats?? It's hard to tell from their description.
Finland: Oats in the treatment of childhood coeliac disease: a 2-year controlled trial and a long-term clinical follow-up study.
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum
Quote:
1: Aliment Pharmacol Ther. 2006 May 15;23(10):1463-72. Links
Holm K,
Maki M,
Vuolteenaho N,
Mustalahti K,
Ashorn M,
Ruuska T,
Kaukinen K.
Department of Paediatrics, Tampere University Hospital, University of Tampere, Tampere, Finland.
BACKGROUND: The exclusion of oats from the diet in coeliac disease is controversial.
AIM: To study the long-term safety of oats in the treatment of children with coeliac disease.
METHODS: Altogether 32 children with coeliac disease were enrolled in a 2-year controlled trial. Twenty-three children in remission were randomized either to oats or gluten challenge; when small bowel histological relapse was evident after gluten challenge, a gluten-free diet including oats was started. Furthermore, nine newly detected coeliac patients adopted an oat-containing gluten-free diet. Small bowel mucosal morphology, CD3+, alphabeta+ and gammadelta+ intraepithelial lymphocytes, human leucocyte antigen (HLA) DR expression and coeliac serology were determined. After the trial, the children were allowed to eat oats freely; follow-up was extended up to 7 years.
RESULTS: In coeliac children in remission, oats had no detrimental effect on intestinal histology or serology during the 2-year trial. In contrast, the gluten-challenge group relapsed after 3-12 months. Complete recovery from the disease was accomplished in all relapsed and newly detected patients on an oat-containing gluten-free diet. After the trial, 86% of the children preferred to consume oats and they all remained in remission.
CONCLUSION: In most children with coeliac disease, long-term consumption of oats is well tolerated, and it does not result in small bowel mucosal deterioration or immune activation.
PMID: 16669961 [PubMed - in process]
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__________________
Al
“We cannot all do great things, but we can do small things with great love.” ~Mother Teresa
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