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Junior Member
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Join Date: May 2012
Location: Hydaburg Alaska
Posts: 73
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Junior Member
Join Date: May 2012
Location: Hydaburg Alaska
Posts: 73
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Hydromorphone, also known as dihydromorphinone, and sold under the brand names Dilaudid among others, is a centrally acting pain medication of the opioid class. It is a derivative of morphine; to be specific, it is a hydrogenated ketone thereof. Comparatively, hydromorphone is to morphine as hydrocodone is to codeine—that is, a semi-synthetic drug.
HYDRO-carbon
The chemical modification of the morphine molecule to hydromorphone results in higher lipid solubility and greater ability to cross the blood–brain barrier to produce more rapid and complete central nervous system penetration.
Hydromorphone is made from morphine either by direct re-arrangement (made by reflux heating of alcoholic or acidic aqueous solution of morphine in the presence of platinum or palladium catalyst) or reduction to dihydromorphine (usually via catalytic hydrogenation), followed by oxidation with benzophenone in presence of potassium tert butoxide or aluminium tert butoxide (Oppenauer oxidation). The 6 ketone group can be replaced with a methylene group via the Wittig reaction to produce 6-Methylenedihydrodesoxymorphine, which is 80× stronger than morphine. mmmmmmmmmmmmm sounds way better than the plants in my garden...GO BIG OIL!!!!
ill take the 4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one instead of that plant over there the guy with the briefcase is eating in his salad......
peace
BP
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