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Old 09-19-2016, 12:50 PM
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mrsD mrsD is offline
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mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

Keep in mind that Tramadol is very slow to act and give results.

It has to be absorbed by the liver first and converted to its active form. This takes time and will be delayed by the presence of food.

Some people lack the liver enzyme to activate tramadol, and for those people there will be little or no response.

This slow to give results sometimes leads people to increase that dose prematurely and if they take extra, there will be a sudden high response when it is metabolized/converted, and hence increased side effects.
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