Plaquenil is well known to help fatigue associated with autoimmune disease.

Although I have never heard of neuropathy caused by its use, the article does say there was two reported cases in New Zealand. However, there are thousands that take it, so the risk must be very low.

That being said, it is imperative to have regular (every 6-12 months) checks by an ophthalmologist for toxicity associated with retinal damage (which can be permanent if not caught early). I have taken Plaquenil for 8 years now and still go every 6 months for eye exams and use a chart every WEEK to check for any signs of vision changes.

As ll medications, you have to weigh the risks vs the benefits.