It's my pleasure, Therese and Brokie did make a remark that I had missed - marginal curve of benefit! The Neupro do have a marginal curve of benefit and its efficacy may not deliver evenly throughout 24 hours. To me, it appears to be a plateau shape distribution of chemical with its peak benefit gradually cumulating up after application (say at hour 2), level-running and then decline gradually (say at hour 18 - 20). Also, be careful that it may peel off after exercise or if your pwp has sweaty skin.

Best

Ling