I'm taking Gralise and I think it was a good switch. I was on 3600mg of Gabapentin, 1200 three times a day, and I would notice more jitteriness and nerve activation when there was a change in my blood level, especially if I was late with a dose. Gralise keeps me much more even in those regards.

I was instructed to take it with dinner and that the 1800mg of Gralise I'm taking is equivalent to my previous 3600 of Gabapentin. Dinner times can vary wildly for me (like, between 6pm and midnight), but I have some straight Gabapentin I can take if it becomes too long since the last dose. I've also taken Gralise without food (such as the night before a colonoscopy), and that's also been fine. Gapapentin is better absorbed when there's fat in the stomach.

Horizant is another time-release Gabapentin with once-a-day dosing. Haven't tried it, but maybe others can weigh in.

And you've probably seen Lyrica mentioned. It requires only twice a day dosing, and I'm told it hits the exact same receptors in the body as Gabapentin does. It didn't work as well as Gabapentin did for me, and I think it was making me gain weight, so I switched back to Gabapentin. As they say, your mileage may vary.