Thanks everyone for your input. We have carefully read the study results from the Georgetown trial and what we got from it was this:

1. two participants withdrew: one because of increased caregiver burden (which is a non-issue to us) and the other apparently had a previously undiagnosed heart issue which was missed on the initial screening. You would certainly want to see a cardiologist before trying this drug to make sure you didn't have any unknown heart issues, and be monitored while on it....

2. with the exception of the participant who withdrew (patient NIL-12), the UPDRS and cognitive scores of 5 of the 6 participants who received the 300mg dose began improving within two months (most began improving earlier) and continued improvement through to week 24 when Tasigna administration was discontinued. The sixth patient who received 300mg ended the 24-week period at the same UPDRS-III score as he/she had at baseline (patient NIL-03, whose score was 12, so no further deterioration which is an improvement in and of itself), and had actually improved on the UPDRS-1-IV score (33 down to 28).

We think that, like many drugs, Tasigna will have no benefit for some PWP but will be life-changing for others. Mirapex, Azilect, and others provide relief for many PWP: yet others cannot tolerate them or worse, suffer horrific side effects.

If anyone knows or has heard of a doc who will script this for PD, please PM me