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Originally Posted by en bloc
I have also had the muscle biopsy at the same time as my sural nerve biopsy (many years ago).
Mine showed denervation atrophy (where the nerve severs from the muscle). But it also showed a process in some areas of reinnervation of previously denervated fibers (which helps to resolve the atrophy in those areas). According to their comments, it is common in some disease processes to have denervation, then reinnervation, then sometimes even going back to denervation. So there can be active and/or inactive process, all depending on whether it is in the denervation or reinnervation stage.
Not sure if any of this is helpful for you. Are the doctors thinking a biopsy is the next step for you? That is odd if you have obvious atrophy, but the MRI doesn't show it. Maybe Glenntaj has some input that would be helpful in this case.
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Thank you both. Apologies for the delay, I've been off neurotalk burying my head in the sand for a while.
Having recently seen a Neuromuscular specialist and having had further MRI's and emg on feet the results are 'no evidence of inflammation or degeneration of muscles'. This 'makes it unlikely that there is an underlying muscle disease accounting for her troublesome symptoms' 'occasionally even though MRI and emg are normal a muscle biopsy can show abnormalities, although this is unusual'
My muscles have changed significantly, I have no padding in my bum and it is like bone to sit on. The structure of my entire legs and bum, hips where Sfn is worst has changed entirely. It looks just like muscle atrophy. I have to pad my lower half out with padded garments. I know this is happening, it has been progressing and doesn't stop. I'm padding out more as time progresses.
Did both of you have certain results that then led to pursuit of a biopsy? We aren't looking at nerve biopsy. Just muscle. Buy the neuro is leaving it for me to decide.
I research all the time but cannot determine how easily MRI's show denervation atrophy (this I believe is what's happening). I just need to know but I know this biopsy is a big procedure.
Has this made a difference to you both I am terms of treatment? I'm diagnosed with Sfn (full body) already