I think that this is a very interesting paper.

One thing that I wonder about is whether or not alpha-synuclein from red blood cells or CSF or plasma can be taken up by neurons in the substantia nigra part of the basal ganglia complex.

In theory this would be easy to test in animal models, seeing if uptake can happen.

If it does happen that would represent a new therapeutic approach for PD (ie, working out how to block alpha-synuclein uptake by those neurons).