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Old 12-05-2016, 08:17 AM
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
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15 yr Member
mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

If you have the common mutation called MTHFR and cannot methylate dietary folic acid and B12, you will test normal or high and still not have ACTIVE B12 to meet your metabolic needs.

This mutation is fairly common (up to 40% of patients now) and the incidence is rising as more people get tested.

These patients may have heterozygous (2 copies of the mutation) or homozygous (one mutation) and the latter allows those people to limp along until some environmental occurance/trigger happens to reveal the problem.

Here is a link to explain in more detail:
MTHFR Mutation | MTHFR Gene Mutation | What is MTHFR? - MTHFR.net

B12 in the diet is mostly unmethylated. If you have damaged intrinsic factor, or the MTHFR genetic mutation, diet is not going to provide enough B12 for you. Methylcobalamin 5mg a day can cost only pennies a day.

This is the link to our B12 thread here on NT at the PN forum:
STICKY - The Vitamin B12 Thread:
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Last edited by mrsD; 12-05-2016 at 09:13 AM.
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