i had one positive sjorgens test about 8 years ago, which a month later was negative and later over the years negative. ANA is up and down. This 1:320 reading is the highest its been. Over the 15 years of my peripheral neuropathy symptoms. the only positive tests that i have ever had are the emg/ncs's showing that i have large fiber primarily axonal sensory motor PN and that it is progressing steadily, and the ANA's. Specific autoimmune antibody markers have all been negative except for that one sjorgens test which has never replicated. I have gotten tested pretty regularly for various autoimmune conditions over the last decade.