From the MIT Technology Review article, which appears to me to be the basis for this Business Insider article:

“…the concept for the Parkinson’s gene therapy dates to 1986, when Bankiewicz first determined that too little AADC was the reason L-Dopa stops working.”

I don’t think I’ve seen it said elsewhere that this is the accepted reason why L-Dopa stops working. Might this be more of a theory than an established fact?

Anyway, they are making good progress, so let’s hope that the next trial confirms their past results!

https://www.technologyreview.com/s/6...-gene-therapy/