Hi Laura, sorry I cannot answer your question,however I do have a question for you-what the heck is Combined Systems Disease??

And I wanted to say that the only doctor (neuro) that ever ordered a B12 test on me had it flagged as too high @ 900. After reading alot of info on the old BT site I began taking B12 Methylcobamin. I had severe cognitive problems @ the time & myoclonus (full body jerks).

Possible MS was also something several docs told me. You might want to take a few minutes to research Lyme & MS (Lyme mimmicks many neuro disorders).

Are you also taking folic acid?

Hopefully someone will be able to answer some of your questions soon!

I also discontinued the use of Splenda & aspartame about the same time I began taking B vits, I rarely suffer severe myolonic attacks these days & have improved ALOT in the brain department.

Take care,Buttons