Thanks Parkinson Fit: a very interesting post.

Here's one of the references that you wanted to make [1].

Interestingly, I'm rs4680 AA too.

I wonder if that explains part of my Parkinson's experience, whereby I wake up in the morning feeling good. Sometimes, I go hours without taking medication, but still function OK.

I see the placebo effect as a friend, not an enemy. We should engineer placebos to have the maximum effect. I feel that a distinction should be made between a true placebo, which really is physiologically inert, and what I call a "therebo" (from THERapy or placEBO), something that may have a direct therapeutic effect, but we're not sure. By this definition I would call your 15 supplements therebos.

Reference:

[1] "Genetics and the Placebo Effect: the Placebome"
Kathryn T. Hall, PhD, MPH Joseph Loscalzo, MD and Ted J. Kaptchuk
Trends Mol Med, 2016, May
Genetics and the Placebo Effect: the Placebome

John