I can't say I know the answer to that for sure. However, It would make sense to me that you would be flushing out some of the medication.
I use to work with teens and when it came time for their drug testing g they would drink gallons of water to flush out their system.
The one thing that may be different with you is the extended relief factor.
Wish I could answer your question definitely.
Your pharmacist would be a good person to pose that question to.