ALA was the one nutrient my husband took that had the greatest impact on his PN. R-ALA was not available back then. We decided to tried the ALA based on how they were using it Germany for diabetic PN. I think they dosed at 900 mg/day.

If memory serves me correctly, John's pain level dropped from an 8 to about the 3-5 range within weeks of starting ALA.

It's certainly worth trying. The only concern I had was with higher dose and how it may impact mercury detoxification. It could mobilize more mercury than your body can handle. But John did fine with it.