View Single Post
Old 12-27-2016, 05:27 PM
MuonOne's Avatar
MuonOne MuonOne is offline
Grand Magnate
 
Join Date: Feb 2007
Posts: 3,279
15 yr Member
MuonOne MuonOne is offline
Grand Magnate
MuonOne's Avatar
 
Join Date: Feb 2007
Posts: 3,279
15 yr Member
Poll

Fast regression ALS patients may have caused anomalous ". . . statistically significant excess mortality . . ." in both DiPALS and RespiStimALS studies. In the set of case I have derived from internet disclosures by patients themselves or their care providers, the number of fast regression limb onset ALS patients is about the same as the number of ordinary bulbar onset ALS patients. Though they are limb onset patients, the fast regression types are often out-lived by the ordinary bulbar onset types. Thus the early 'fall-out' of patients includes the fast regression types as well as bulbar onset types and appears therefore larger than expected but such losses are not abnormal. In my study of about 176 cases there are about as many fast regression limb onset cases as there are ordinary onset bulbar cases in the 'early fallout.' An ordinary sample of ALS patients likely reflects five to ten percent fast regression limb onset cases. They are present in about the same number as ordinary bulbar onset patients but are significantly fewer than the overall number of bulbar onset patients, who sometimes manage to live more than ten years.
MuonOne is offline   Reply With QuoteReply With Quote