Much is written regarding the unpredictability of the effect of ALS on any given individual: Prognosis. Some time ago, Prize4Life launched the prediction challenge and drew the attention of many teams of scholars in competition to develop algorithms to predict life expectancy and last year several teams were awarded prizes:

Completion announcement
Prize4Life, Sage Bionetworks and DREAM Announce Winners of ALS Stratification Challenge | Business Wire

Scores
Sage Synapse : Contribute to the Cure

The PRO-ACT database was deployed to provide data for the algorithms to evaluate:

PRO-ACT - HOME

While some impressive results developed, no one considers the regression caused by the ALS syndrome to be predictable.