Originally Posted by mrsD

Here is a study done on animals that shows the micronized forms working better than non-micronized forms. (2014)

Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain

So solubility IS a factor, and if anyone here wants to try this PEA, then I'd suggest you get the micronized version.