My wife has been on Nuplazid for about 4 weeks now. She still has the hallucinations and delusions but she may be more calm and reasonable. The drug is Very Expensive, I pay $40 copay for 30 day Rx. It take about 6 weeks to show its effectiveness but nothing dramatic so far.
My wife is/has been on Seroquel, Geodone, Mirtazapine and has had 16! ECT treatments (this summer). Nothing has helped much with the psychosis (many ER visits). If the Nuplazid does not work I think they'll try Clozapine and if that doesn't work it's a nursing home?