Quick answer YES, in any way possible try to stay away from PREDISONE it has adverse side effects! and once you start you can't stop suddenly, with Imuran it's the total opposite.

In my case I'm still having problems from PREDISONE...It took forever to wean off, I've been off since June 2016.

Imuran's downfall is that it takes longer to have it's full effect, it took me 8 months as I was also taking Prednisone at the same time waiting for the Imuran to come to its fullest effect then we started weaning off Preds and that alone was a rough ride...I have intense muscle pain ever since, quads and arms...

I'm sure others will Chime in and attest to Predisone side effects...If you can live with your symptoms and give the Imuran a chance to reach its fullest that's the route I would take...

Talk to your Neurologist about it and see what he/she thinks about it.Do some research on Preds and make your assomption based on what you feel comfortable with.

Good luck.