My neuro has told me that we can not do any more injections since I had such a nasty reaction to Plegridy and Copaxone, Plegridy being the worst. He says the rest are Interferon based. Tysabri is completely out of the equation since I am JCV positive. I am going to go for my labs in the morning so my annual MRI's can be scheduled and we are going to try Tecfidera, as long as my lymphocytes are ok. He told me if I get so much as a dime sized rash, he will discontinue the drug. I know my white count dropped with Copaxone and I was only able to do 5 injections. My symptoms are beginning to get worse and bothersome. Has anyone had experience with Tecfidera? Any experience or opinions are appreciated. Thanks.