Thread: Zinc levels in Parkinson's patients much lower than healthy controls:
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Old 02-08-2017, 09:45 AM
johnt johnt is offline
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johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
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A broader discussion of serum metal levels in PD can be found in a thread from 2012:

Serum metal levels

To quote from that thread:

Ahmed and Santosh [1] measured the serum levels of various metals in PD (n=45) and non-PD (n=42) people in South India.

They found that "Al [high in PwP], Cu [high], Fe [low], Mn [high] and Zn [low] were dominantly reponsible for the separation of PD from normal".

They went on to look at the correlation between metal ratios and PD: "Al/Cu, Al/Fe, Al/Mn, Al/Zn, Cu/Fe, Cu/Zn, Fe/Zn and Mn/Zn were increased and Fe/Mn and Cu/Mn were decreased in PD compared to healthy control".

They describe a neural network (a computing technique, ironically inspired by the working of the brain) which, taking together all the relationships, gives a 95% diagnostic accuracy. (But, note the small sample size.)

Reference

[1] Ahmed SSSJ, Santosh W (2010) Metallomic Profiling and Linkage Map Analysis of Early Parkinson's Disease: A New Insight to Aluminum Marker for the Possible Diagnosis. PLoS ONE 5(6): e11252. doi:10.1371/journal.pone.0011252
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John
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Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
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