Jeff, Your points are well taken. However, in order for the researchers to distill valid data, as many parameters as possible need to remain constant. For two days I experimented with the dosage and then decided my discomfort was less important than valid data so I went back to the Sinemet doses of 1 at 7, 10, 1 and 1/2 at 4 and 7.

The tremor only happens in a 10-15 minute time frame around pills at 4 and 7 p.m., and that's not always. That's generally true for the dyskinesia as well. When I was taking the full pill at 4 pm. the dyskinesia was very much in evidence. Now it is still there, but not nearly as noticeable.