I think that you have made a good point jeffreyn.
There are a few papers out there which suggest similar findings for calcineurin and α-synuclein-mediated neurotoxicity.
This is the most recent free-access one that I can find
PNAS Plus: Calcineurin determines toxic versus beneficial responses to α-synuclein.
It is interesting but is mainly based on tissue culture and yeast models.