Hi, Skgroom. Yeah, it's pretty hard to get off of Pred. Have they tried reducing the dose in very small increments?

Are you on Mestinon? If so, Cimetidine may keep Mestinon in the neuromuscular junction longer.

The reason Pred messes with the stomach is that the drug is an antiprostaglandin. It reduces the gel coating of the stomach. To improve that situation, you can have good omega 3's daily, such as olive oil, flax oil, or walnuts. You could eat fish. Reducing stomach acid may initially help, but it doesn't solve the gel coating issue.

What Cimetidine has been found to do is to reduce acetylcholinesterase, the enzyme that mops up acetylcholine. In other words, it has the same effect of Mestinon, to an unknown degree.

Cholinergic effects of histamine-H2 receptor antagonists partly through inhibition of acetylcholinesterase. - PubMed - NCBI

I agree with Mrs. D. Don't play around with meds that have not been directly tested on MG AND may have adverse effects on other systems in the body. H2-receptor antagonists can lead to deficiencies such as B12, iron, calcium, and protein/albumin.

You have good instincts. Just don't become a medical mistake by using a med not specific to MG. Cimetidine certainly isn't a substitute for Pred, nor will it help withdraw from it!

Please talk to your neuro about your options.

Annie