yes it is important not to play with your meds, I informed my specialist that I was taking cimetidine 200mg, first thing in the morning, and than my prednisone 10mg, about an hour later with food, she felt this was fine. We have tried to slowly ween off the prednisone, with no luck, once I get down to about 5mg, my symptoms come back, so I have just come to the conclusion I will be on prednisone for life. Occasionally I have more of a flair up, but since I have been taking cimetidine, that hasn't happen. I guess my thought is, if it's helped me, maybe it can help someone else, of course they need to consult their doctor first. I have struggle with this for so long, trying to find something that would work, or at least make me feel, a little normal, and l'm just wondering if it's a fluke, or could there be some merit, I wish more research could be done.