Hi there i have hypothyroidism i take synthroid .150 i was told i had it about 6 yrs ago. My doctor was only doing once a year blood work but now she checks my liver every 6 months she checks my thyroid at the same time. I never thought about it affecting my tos. Oh and i am happy to say that my liver is fine to but she keeps a close eye on since i have started all the pain pills i am on. But now that i have read your threads i do belive that the second year of pain she did have to put my pill up from 125 to 150 it only seem to make me feel good for about a week. Then i felt the same as before so i guess it could affect how one feels having tos and thyroid at the same time. I will have to ask my doc when i see her next month. One thing first do any of yous have trouble with your memory?